Ischemia-modified albumin as an oxidative stress marker in preeclampsia

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 24; no. 3; pp. 418 - 421
• Main Authors: Üstün, Yusuf, Engin-Üstün, Yaprak, Öztürk, Özlem, Alanbay, Ibrahim, Yaman, Halil
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01-03-2011; Taylor & Francis
• Subjects: Adult; Biomarkers - analysis; Biomarkers - blood; Biomarkers - metabolism; Case-Control Studies; Cross-Sectional Studies; Female; Humans; ischaemia-modified albumin; Ischemia - blood; Ischemia - complications; Oxidative Stress - physiology; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Protein Processing, Post-Translational; Serum Albumin - chemistry; Serum Albumin - metabolism; Severity of Illness Index; Young Adult
• ISSN: 1476-7058; 1476-4954
• DOI: 10.3109/14767058.2010.497879

Objective. We examined serum ischaemia-modified albumin (IMA) levels in normal pregnant and preeclamptic women. The primary aim of our study was to assess IMA in women with mild and severe preeclampsia.
Methods. Serum ischaemia-modified albumin levels were measured in 18 normotensive and 36 preeclamptic pregnant women by enzyme linked immuno-sorbent assay. Patients were subdivided as having either mild (n = 18) or severe preeclampsia (n = 18). Receiver operating characteristic curve was constructed, and sensitivity and specificity were calculated based on the best cut-off.
Results. IMA levels were significantly higher in the mild and severe preeclamptic groups than in the control group. IMA with a cut-off point of 0.31 identified women with preeclampsia with sensitivity 80% and specificity 77.8%.
Conclusion. Our study demonstrates that serum levels of IMA correlate with severity of preeclampsia.