TPC1 - SV Channels Gain Shape

The most prominent ion channel localized in plant vacuoles is the slow activating SV type. Slow vacuolar （SV） channels were discovered by patch clamp studies as early as 1986. In the following two decades, numerous studies revealed that these calcium- and voltage-activated, nonselective cation chann...

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Bibliographic Details
Published in:	Molecular Plant Vol. 4; no. 3; pp. 428 - 441
Main Authors:	Hedrich, Rainer, Marten, Irene
Format:	Journal Article Book Review
Language:	English
Published:	England Elsevier Inc 01-05-2011 Cell Press
Subjects:	Arabidopsis - physiology Biological Transport Calcium Channels - chemistry Calcium Channels - genetics Calcium Channels - metabolism CICR Conserved Sequence - genetics Intracellular Membranes - metabolism Proteins SV channel SV通道 TPC1 vacuole transport Vacuoles - metabolism 基因编码增益形状植物组织氧化还原状态电压依赖性离子通道 SV channel vacuole transport CICR TPC1
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Summary:	The most prominent ion channel localized in plant vacuoles is the slow activating SV type. Slow vacuolar （SV） channels were discovered by patch clamp studies as early as 1986. In the following two decades, numerous studies revealed that these calcium- and voltage-activated, nonselective cation channels are expressed in the vacuoles of all plants and every plant tissue. The voltage-dependent properties of the SV channel are susceptible to modulation by calcium, pH, redox state, as well as regulatory proteins. In Arabidopsis, the SV channel is encoded by the AtTPC1 gene, and even though its gene product represents the by far largest conductance of the vacuolar membrane, tpcl-loss-of-function mutants appeared not to be impaired in major physiological functions such as growth, development, and reproduction. In contrast, the fou2 gain-of-function point mutation D454N within TPC1 leads to a pronounced growth phenotype and increased synthesis of the stress hormone jasmonate. Since the TPC1 gene is present in all land plants, it likely encodes a very general function. In this review, we will discuss major SV channel properties and their impact on plant cell physiology.
Bibliography:	31-2013/Q The most prominent ion channel localized in plant vacuoles is the slow activating SV type. Slow vacuolar （SV） channels were discovered by patch clamp studies as early as 1986. In the following two decades, numerous studies revealed that these calcium- and voltage-activated, nonselective cation channels are expressed in the vacuoles of all plants and every plant tissue. The voltage-dependent properties of the SV channel are susceptible to modulation by calcium, pH, redox state, as well as regulatory proteins. In Arabidopsis, the SV channel is encoded by the AtTPC1 gene, and even though its gene product represents the by far largest conductance of the vacuolar membrane, tpcl-loss-of-function mutants appeared not to be impaired in major physiological functions such as growth, development, and reproduction. In contrast, the fou2 gain-of-function point mutation D454N within TPC1 leads to a pronounced growth phenotype and increased synthesis of the stress hormone jasmonate. Since the TPC1 gene is present in all land plants, it likely encodes a very general function. In this review, we will discuss major SV channel properties and their impact on plant cell physiology. SV channel; TPC1; vacuole transport; CICR. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1674-2052 1752-9867
DOI:	10.1093/mp/ssr017