The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway

• Published in: Cancer letters Vol. 371; no. 2; pp. 251 - 261
• Main Authors: Hung, Amos C, Tsai, Chun-Hao, Hou, Ming-Feng, Chang, Wen-Lin, Wang, Chie-Hong, Lee, Yi-Chen, Ko, Alice, Hu, Stephen Chu-Sung, Chang, Fang-Rong, Hsieh, Pei-Wen, Yuan, Shyng-Shiou F
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28-02-2016
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antioxidants - pharmacology; Apoptosis Regulatory Proteins - metabolism; Autophagy - drug effects; Autophagy-Related Protein 5; Beclin-1; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - enzymology; Breast Neoplasms - ultrastructure; Caspases - metabolism; Cell Survival - drug effects; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; G2 Phase Cell Cycle Checkpoints - drug effects; Hematology, Oncology and Palliative Medicine; Histones - metabolism; Humans; MCF-7 Cells; MEK/ERK; Membrane Proteins - metabolism; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins - metabolism; Mitogen-Activated Protein Kinase Kinases - metabolism; Oxidative Stress - drug effects; Phosphorylation; Poly(ADP-ribose) Polymerases - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Styrenes - pharmacology; Xenograft Model Antitumor Assays; β-Nitrostyrene; Reactive oxygen species; Breast cancer; β-Nitrostyrene; MEK/ERK
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.11.035

Highlights • The synthetic β-nitrostyrene derivative CYT-Rx20 induced breast cancer cell death. • CYT-Rx20 induced breast cancer cell death via ROS and MEK/ERK regulation. • CYT-Rx20 induced autophagy in breast cancer cells. • CYT-Rx20 induced autophagy via ROS and MEK/ERK regulation. • CYT-Rx20 inhibited orthotopic tumor growth in vivo.