Endobronchial brachytherapy for metastasis from extrapulmonary malignancies as an effective treatment for palliation of symptoms

• Published in: Brachytherapy Vol. 16; no. 3; pp. 630 - 638
• Main Authors: Donovan, E, Timotin, E, Farrell, T, Donde, B, Puksa, S, Sur, R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2017
• Subjects: Brachytherapy; Brachytherapy - methods; Bronchial Neoplasms - complications; Bronchial Neoplasms - radiotherapy; Bronchial Neoplasms - secondary; Chest Pain - etiology; Cough - etiology; Disease-Free Survival; Dose Fractionation; Dyspnea; Dyspnea - etiology; Endobronchial metastasis; Female; Hematology, Oncology and Palliative Medicine; Hemoptysis; Hemoptysis - etiology; Humans; Male; Palliation; Palliative Care - methods; Prospective Studies; Radiology; Survival Rate; Symptom Assessment; Treatment Outcome; Hemoptysis; Brachytherapy; Endobronchial metastasis; Dyspnea; Palliation
• ISSN: 1538-4721; 1873-1449
• DOI: 10.1016/j.brachy.2017.01.003

Abstract Purpose Endobronchial metastasis (EBM) originating from primary cancers outside the lung is rare. External beam radiotherapy is often attempted for control of symptoms with variable effectiveness and retreatment is challenging if symptoms recur. There is limited documentation of high-dose-rate brachytherapy for EBM in the literature. Methods and Materials A prospective database was created from 2006 to 2015. Patients with EBM who received high-dose-rate brachytherapy were included. Cough, dyspnea, chest pain, and hemoptysis were assessed and graded (0-4) at the time of initial consult and in followup. Symptom-free survival and re-expansion were assessed. Results Thirty-five patients with EBM were identified. Most patients received three fractions of 700 cGy, and 17 patients had prior external beam radiotherapy. Median symptom-free and overall survival were 67 and 117 days. After brachytherapy, improvement in cough was documented in 75.0%, hemoptysis in 76.4%, dyspnea in 60.0% for a median of 3-6 months. Of the 22 patients who had subsequent chest imaging, re-expansion was documented in 32%. There were no significant toxicities reported. Conclusions Brachytherapy appears effective in achieving durable symptom control of cough hemoptysis, and dyspnea in patients with EBM and should be considered routinely for palliation where available. Further studies are required to better characterize expected symptom improvement, lung re-expansion rates, and efficacy in comparison with other local treatments.