Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study

• Published in: The Journal of infectious diseases Vol. 208; no. 9; pp. 1454 - 1458
• Main Authors: Wandeler, Gilles, Gsponer, Thomas, Bihl, Florian, Bernasconi, Enos, Cavassini, Matthias, Kovari, Helen, Schmid, Patrick, Battegay, Manuel, Calmy, Alexandra, Egger, Matthias, Furrer, Hansjakob, Rauch, Andri
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-11-2013
• Subjects: Adult; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Biological and medical sciences; CD4 Lymphocyte Count; Coinfection - drug therapy; Coinfection - immunology; Coinfection - virology; Female; Fundamental and applied biological sciences. Psychology; Hepatitis B virus; Hepatitis B virus - drug effects; Hepatitis B virus - immunology; Hepatitis B, Chronic - drug therapy; Hepatitis B, Chronic - immunology; Hepatitis B, Chronic - virology; HIV - drug effects; HIV - immunology; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Prospective Studies; Treatment Outcome; Viral diseases; Viral hepatitis; Virology; Antiretroviral agent; Retroviridae; Hepatic disease; Lentivirus; Virus; Viral hepatitis B; Infection; Treatment; Viral disease; Cohort study; Digestive diseases; Antiviral; Human immunodeficiency virus; immunological recovery; anti-hepatitis B core antigen alone; hepatitis B infection; antiretroviral therapy outcomes
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jit351

Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.