AAN position statement: Ethical issues in clinical research in neurology

AAN position statement: Ethical issues in clinical research in neurology

This update to the American Academy of Neurology’s 1998 position statement endeavors to provide guidance for the consistent ethical conduct and review of neurologic research involving human participants. It does so by outlining a widely used ethical framework of 7 principles derived from the foundat...

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Bibliographic Details
Published in:Neurology Vol. 94; no. 15; pp. 661 - 669
Main Authors: Tolchin, Benjamin, Conwit, Robin, Epstein, Leon G., Russell, James A.
Format: Journal Article
Language:English
Published: United States American Academy of Neurology 14-04-2020
Lippincott Williams & Wilkins
Subjects:
Bioethics
Biomedical Research - ethics
Humans
Informed Consent - ethics
Neurology - ethics
Societies, Medical - ethics
Special
United States
United States
Online Access:Get full text
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Summary:This update to the American Academy of Neurology’s 1998 position statement endeavors to provide guidance for the consistent ethical conduct and review of neurologic research involving human participants. It does so by outlining a widely used ethical framework of 7 principles derived from the foundational documents of modern bioethics, including the Nuremberg Code, the World Medical Association’s Declaration of Helsinki, the Belmont Report, and the US Department of Health and Human Service’s Common Rule. The position statement then applies this principle-based framework to analyze and produce recommendations for the management of common and important ethical issues encountered in neurologic clinical research. These include institutional review board oversight, equitable research participant inclusion, cognitive impairment in research participants, international studies, the replication crisis, and genetic testing and modification.
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These authors contributed equally to this work.
This American Academy of Neurology position statement has been endorsed by the American Neurologic Association and the Child Neurology Society.
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
ISSN:0028-3878
1526-632X
DOI:10.1212/WNL.0000000000009241