Adenocarcinoma arising from a mature cystic teratoma of the testis

• Published in: International journal of urology Vol. 10; no. 9; pp. 505 - 509
• Main Authors: KASAI, TOSHINORI, MORIYAMA, KAZUMICHI, TSUJI, MASAHITO, UEMA, KENZO, SAKURAI, NORITSUGU, FUJII, YOSHIYUKI
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01-09-2003
• Subjects: adenocarcinoma; Adenocarcinoma, Mucinous - diagnosis; Adenocarcinoma, Mucinous - secondary; Adenocarcinoma, Mucinous - surgery; Dermoid Cyst - diagnosis; Dermoid Cyst - surgery; Fatal Outcome; Humans; Male; malignant transformation; mature cystic teratoma (dermoid cyst); Middle Aged; Orchiectomy; Skin Neoplasms - secondary; Teratoma - diagnosis; Teratoma - surgery; Testicular Neoplasms - diagnosis; Testicular Neoplasms - surgery; testis
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1046/j.1442-2042.2003.00670.x

A 52‐year‐old male diagnosed pathologically with metastatic adenocarcinoma of the skin was referred to our department. Physical examination revealed a right scrotal mass the size of child's head and several skin tumors. Right high orchiectomy and resection of skin tumors were performed. Histopathological examination revealed a well‐differentiated, mucinous adenocarcinoma originating from the gastrointestinal epithelium in a mature cystic teratoma (dermoid cyst) of the testis and metastatic mucinous adenocarcinoma of the skin. We made a diagnosis of teratoma with malignant transformation (TMT) of the testis. Combination chemotherapy with low‐dose cisplatin/5′‐deoxy‐5‐fluorouridine (CDDP/5′‐DFUR) was initiated, but the patient died 8 months after orchiectomy. At autopsy, similar mucinous adenocarcinoma of the testis and the skin were observed at the metastatic sites.