Antimicrobials: targeting virulence genes necessary for intracellular multiplication

Intracellular bacteria constitute a major class of pathogens for humans and animals. Their pathogenicity is linked to their ability to multiply inside a host cell. A set of virulence genes (virulome) is required for this intracellular lifestyle. Recent studies have shown that blocking the enzymes en...

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Bibliographic Details
Published in:	Trends in microbiology (Regular ed.) Vol. 14; no. 3; pp. 109 - 113
Main Authors:	Liautard, Jean-Pierre, Jubier-Maurin, Véronique, Boigegrain, Rose-Anne, Köhler, Stephan
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-2006 Elsevier
Subjects:	Animals Anti-Bacterial Agents - pharmacology Bacteria - enzymology Bacteria - genetics Bacteria - growth & development Bacteria - pathogenicity Bacteriology Enzyme Inhibitors - pharmacology Humans Life Sciences Microbiology and Parasitology Virulence - genetics Virulence Factors - antagonists & inhibitors Virulence Factors - genetics
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Summary:	Intracellular bacteria constitute a major class of pathogens for humans and animals. Their pathogenicity is linked to their ability to multiply inside a host cell. A set of virulence genes (virulome) is required for this intracellular lifestyle. Recent studies have shown that blocking the enzymes encoded by these virulence genes impairs intracellular multiplication of the pathogen. These specific factors could constitute a new set of possible targets for antimicrobial drugs. The potential advantages, pitfalls and challenges of a strategy that targets these virulence factors are discussed.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2006.01.005