Radiation-induced cholangitis with hepatocellular carcinoma

• Published in: Gastroentérologie clinique et biologique Vol. 34; no. 1; pp. 35 - 39
• Main Authors: Gorea, G., Demy, M., Tran Van Nhieu, J., Tigori, J., Aubé, C., Cherqui, D., Oberti, F., Caroli-Bosc, F.-X., Calès, P.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 2010; Masson; Elsevier Masson
• Subjects: Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Carcinoma, Hepatocellular - diagnosis; Cholangitis - complications; Cholangitis - etiology; Common Bile Duct Diseases - complications; Constriction, Pathologic - complications; Fatal Outcome; Gastroenterology. Liver. Pancreas. Abdomen; Hodgkin Disease - radiotherapy; Human bacterial diseases; Humans; Incidental Findings; Infectious diseases; Life Sciences; Liver Neoplasms - diagnosis; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Radiotherapy - adverse effects; Tumors; Infection; Cholangitis; Gastroenterology; Bacteriosis; Radiation injury; Digestive diseases; Hepatic disease; Hepatocellular carcinoma; Malignant tumor; Biliary tract disease; Cancer
• ISSN: 0399-8320
• DOI: 10.1016/j.gcb.2009.06.013

There are no reports of hepatocellular carcinoma complicating postradiotherapy cholangitis. We report the case of a 45-year-old patient who had undergone upper abdominal radiotherapy for Hodgkin's disease, 21 years before, which was complicated years later by cholangitis with stricture of the common bile duct. Biliodigestive anastomosic surgery was scheduled due to recurrent angiocholitis, and hepatocellular carcinoma was discovered. The patient died from carcinoma some months later.
Il n’a pas été décrit dans la littérature, de cas de carcinome hépatocellulaire compliquant une cholangite postradique. Nous rapportons ici le cas d’un homme de 45 ans ayant bénéficié d’une radiothérapie pour maladie de Hodgkin, 21 ans auparavant. Cette radiothérapie a été compliquée, après une longue évolution, d’une cholangite postradique avec sténose de la voie biliaire principale. La survenue d’angiocholites récurrentes nous a conduit à pratiquer une anastomose biliodigestive au cours de laquelle un carcinome hépatocellulaire a été découvert. Le patient est décédé quelques mois plus tard.