Relationship Between Plasma Endothelin-1 Levels and Myocardial Ischemia Induced by Exercise Testing

• Published in: The American journal of cardiology Vol. 79; no. 7; pp. 957 - 959
• Main Authors: Fontana, Fiorella, Tarsi, Giovanni, Boschi, Stefano, De Iasio, Rosaria, Monetti, Nino, Bugiardini, Raffaele
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-04-1997; Elsevier; Elsevier Limited
• Subjects: Angina Pectoris - blood; Angina Pectoris - diagnosis; Angina Pectoris - diagnostic imaging; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; Case-Control Studies; Coronary heart disease; Endothelin-1 - blood; Exercise; Exercise Test; Female; Heart; Heart - diagnostic imaging; Humans; Male; Medical research; Medical sciences; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - diagnosis; Myocardial Ischemia - diagnostic imaging; Plasma; Radionuclide Imaging; Thallium Radioisotopes; Human; Plasma; Concentration factor; Cardiovascular disease; Endothelin 1; Coronary heart disease; Myocardial disease; Statistical study; Vascular disease; Assay; Ischemia; Myocardium; Exercise tolerance test
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(97)00019-2

At peak exercise, plasma endothelin-1 concentration increases in patients with effort angina as well as thallium-201 radionuclide perfusion defects; the opposite occurs in patients with normal scans and in healthy volunteers. It is concluded that exercise-induced ischemia correlates with enhanced endothelin-1 production.