Effects of phosphorus intake on phosphorus flow in growing pigs: Application and comparison of two models

• Published in: Journal of theoretical biology Vol. 236; no. 2; pp. 115 - 125
• Main Authors: Schulin-Zeuthen, M., Lopes, J.B., Kebreab, E., Vitti, D.M.S.S., Abdalla, A.L., Haddad, M.DeL, Crompton, L.A., France, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21-09-2005
• Subjects: Animal Feed; Animals; Balance studies; Biological Transport; Biomarkers - urine; Bone and Bones - metabolism; Bone Development - physiology; Goats; Growing pigs; Homeostasis; Intestinal Absorption - physiology; Isotope dilution techniques; Kinetic models; Models, Biological; Phosphorus; Phosphorus - metabolism; Phosphorus, Dietary - metabolism; Radioisotope Dilution Technique; Swine; Isotope dilution techniques; Growing pigs; Phosphorus; Balance studies; Kinetic models
• ISSN: 0022-5193; 1095-8541
• DOI: 10.1016/j.jtbi.2005.02.021

A comparison of the models of Vitti et al. (2000, J. Anim. Sci. 78, 2706–2712) and Fernández (1995c, Livest. Prod. Sci. 41, 255–261) was carried out using two data sets on growing pigs as input. The two models compared were based on similar basic principles, although their aims and calculations differed. The Vitti model employs the rate:state formalism and describes phosphorus (P) flow between four pools representing P content in gut, blood, bone and soft tissue in growing goats. The Fernández model describes flow and fractional recirculation between P pools in gut, blood and bone in growing pigs. The results from both models showed similar trends for P absorption from gut to blood and net retention in bone with increasing P intake, with the exception of the 65
kg results from Date Set 2 calculated using the Fernández model. Endogenous loss from blood back to gut increased faster with increasing P intake in the Fernández than in the Vitti model for Data Set 1. However, for Data Set 2, endogenous loss increased with increasing P intake using the Vitti model, but decreased when calculated using the Fernández model. Incorporation of P into bone was not influenced by intake in the Fernández model, while in the Vitti model there was an increasing trend. The Fernández model produced a pattern of decreasing resorption in bone with increasing P intake, with one of the data sets, which was not observed when using the Vitti model. The pigs maintained their P homeostasis in blood by regulation of P excretion in urine.