Association of Intentional Changes in Body Weight with Coronary Heart Disease Event Rates in Overweight Subjects Who Have an Additional Coronary Risk Factor

• Published in: American journal of epidemiology Vol. 161; no. 4; pp. 352 - 358
• Main Authors: Eilat-Adar, Sigal, Eldar, Michael, Goldbourt, Uri
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 15-02-2005; Oxford Publishing Limited (England)
• Subjects: Aged; Analysis. Health state; Biological and medical sciences; BMI; Body fat; Body Mass Index; body weight; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular Surgical Procedures; CHD; confidence interval; coronary disease; Coronary Disease - etiology; Coronary Disease - mortality; Coronary Disease - prevention & control; Coronary heart disease; counseling; Directive Counseling; Epidemiology; Female; Follow-Up Studies; General aspects; Health risk assessment; Heart; Humans; Incidence; Male; Medical sciences; Metabolic diseases; Middle Aged; nutrition; Obesity; Obesity - complications; Obesity - diet therapy; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk Factors; standard deviation; Weight control; Weight Loss; Human; Prognosis; Nutrition; counseling; Psychological counseling; Body weight; Coronary artery; Weight loss; Cardiovascular disease; Coronary heart disease; Epidemiology; Feeding; Overweight; coronary disease; Association; Risk factor
• ISSN: 0002-9262; 1476-6256; 0002-9262
• DOI: 10.1093/aje/kwi045

Despite evidence that weight loss improves the severity of coronary heart disease (CHD) risk factors, a direct association between weight loss and CHD incidence has not been demonstrated. In 1994–2001, the authors conducted an observational study of intentional weight loss as related to CHD incidence among patients recruited from a network of clinics in Israel who received nutritional counseling from a dietitian to support the medical recommendation to lose weight. Subjects were outpatients aged 50–75 years with a body mass index of ≥27 kg/m2, without CHD or cancer but with at least one risk factor for CHD in addition to overweight. Outcomes were documented over 4 years by repeated weight measurements and by medical record verification. Among 1,669 patients, 224 (13.4%) incidents of CHD were recorded. For subjects who underwent at least 6 months of dietetic counseling, the risk-factor-adjusted odds ratio for CHD incidence associated with a weight loss of 4.5 kg (the median level of weight loss) was 0.57 (95% confidence interval: 0.39, 0.84). In this, the largest known study of its type reported to date, intentional weight loss from a 6-month diet predicted lower incidence of CHD over 4 years.