Arterial Stiffness and Stroke in Sickle Cell Disease

• Published in: Stroke (1970) Vol. 43; no. 4; pp. 1129 - 1130
• Main Authors: BELIZNA, Cristina, LOUFRANI, Laurent, GHALI, Alaa, LAHARY, Agnes, PRIMARD, Etienne, LOUVEL, Jean-Pierre, HENRION, Daniel, LEVESQUE, Hervé, IFRAH, Norbert
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01-04-2012; American Heart Association
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - diagnostic imaging; Anemia, Sickle Cell - physiopathology; Biological and medical sciences; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Life Sciences; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Stroke - diagnostic imaging; Stroke - etiology; Stroke - physiopathology; Ultrasonography, Doppler, Transcranial; Vascular diseases and vascular malformations of the nervous system; Vascular Stiffness; arterial stiffness; Hemoglobinopathy; Stroke; Nervous system diseases; Sickle cell anemia; Cardiovascular disease; Hemopathy; Genetic disease; Cerebral disorder; sickle cell disease; Vascular disease; Hemolytic anemia; Central nervous system disease; Cerebrovascular disease; Transcranial; Stroke/etiology/physiopathology/ultrasonography; Anemia; Humans; Adolescent; Ultrasonography; Adult; Female; Male; Sickle Cell/complications/physiopathology/ultrasonography; Vascular Stiffness; Doppler
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.111.635383

Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke.
Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured.
Arterial stiffness and transcranial Doppler velocity were significantly increased in 49 patients with sickle cell disease compared with 47 control subjects (P<0.05) and especially in patients with stroke (P<0.05).
These data suggest that transcranial Doppler and arterial stiffness might be associated to stroke in adult patients with sickle cell disease.