Usefulness of pindolol in neurocardiogenic syncope

• Published in: The American journal of cardiology Vol. 82; no. 9; pp. 1121 - 1124
• Main Authors: Iskos, Demosthenes, Dutton, John, Scheinman, Melvin M., Lurie, Keith G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-11-1998; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adrenergic beta-Antagonists - therapeutic use; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cardiovascular disease; Drug therapy; Female; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Neurology; Neuropharmacology; Pharmacology. Drug treatments; Pindolol - therapeutic use; Prospective Studies; Syncope, Vasovagal - diagnosis; Syncope, Vasovagal - drug therapy; Syncope, Vasovagal - prevention & control; Tilt-Table Test; Treatment Outcome; Human; Head position; Nervous system diseases; Consciousness impairment; Treatment efficiency; Vasovagal syncope; Intrinsic sympathomimetic activity; Chemotherapy; Treatment; Test; Diseases of the autonomic nervous system; Neurological disorder; Beta blocking agent; Pindolol
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(98)00568-2

We prospectively studied the efficacy of pindolol, a beta-adrenergic blocker with intrinsic sympathomimetic activity (ISA), for the prevention of syncope recurrences in 31 patients with recurrent neurocardiogenic syncope. Pindolol proved to be an effective treatment, even in patients who had previously failed treatment with conventional beta blockers, suggesting a clinical benefit from addition of ISA to beta blockade in this setting.