Relation Between Amiodarone and Desethylamiodarone Plasma Concentrations and Ventricular Defibrillation Energy Requirements

• Published in: The American journal of cardiology Vol. 79; no. 1; pp. 97 - 100
• Main Authors: Daoud, Emile G, Man, K.Ching, Horwood, Laura, Morady, Fred, Strickberger, S.Adam
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-01-1997; Elsevier; Elsevier Limited
• Subjects: Aged; Amiodarone - analogs & derivatives; Amiodarone - blood; Antiarythmic agents; Biological and medical sciences; Cardiovascular system; Coronary vessels; Defibrillators, Implantable; Drug therapy; Electric Countershock; Female; Heart; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Plasma; Prospective Studies; Human; Intensive cardiocirculatory care; Interaction; Instrumentation therapy; Amiodarone; Concentration; Antiarrhythmic agent; Iodine Organic compounds; Blood plasma; Chemotherapy; Treatment; Energy; Implanted; Defibrillation; Defibrillator
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(96)00689-3

The main finding of this prospective, controlled study is that amiodarone and desethylamiodarone plasma concentrations < 1 mg/L are associated with a 23% increase in the acute defibrillation energy requirement and with a 31% increase in the requirement for a subcutaneous patch or array. The defibrillation energy requirement does not correlate with the plasma concentrations of amiodarone, desethylamiodarone, amiodarone plus desethylamiodarone, or with the duration or daily dosage of amiodarone therapy.