Superparamagnetic nickel colloidal nanocrystal clusters with antibacterial activity and bacteria binding ability

• Published in: Nature nanotechnology Vol. 13; no. 6; pp. 478 - 482
• Main Authors: Peng, Bo, Zhang, Xinglin, Aarts, Dirk G. A. L., Dullens, Roel P. A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-06-2018; Nature Publishing Group
• Subjects: 140/146; 639/301/357/354; 639/925/350/354; Antibacterial activity; Antimicrobial activity; Antimicrobial agents; Bacteria; Binding; Chemistry and Materials Science; Clusters; E coli; Food preservation; Heavy metals; Historical metallurgy; Letter; Materials Science; Microbiology; Microorganisms; Nanocrystals; Nanoparticles; Nanotechnology; Nanotechnology and Microengineering; Nickel; Pyrolysis; Spores
• ISSN: 1748-3387; 1748-3395
• DOI: 10.1038/s41565-018-0108-0

Recent progress in synthetic nanotechnology and the ancient use of metals in food preservation and the antibacterial treatment of wounds have prompted the development of nanometallic materials for antimicrobial applications
1
–
4
. However, the materials designed so far do not simultaneously display antimicrobial activity and the capability of binding and capturing bacteria and spores. Here, we develop a one-step pyrolysis procedure to synthesize monodisperse superparamagnetic nickel colloidal nanocrystal clusters (SNCNCs), which show both antibacterial activity and the ability to bind Gram-positive (
Bacillus subtilis
) and Gram-negative (
Escherichia coli
) bacteria, as well as bacterial spores. The SNCNCs are formed from a rapid burst of nickel nanoparticles, which self-assemble slowly into clusters. The clusters can magnetically extract 99.99% of bacteria and spores and provide a promising approach for the removal of microbes, including hard-to-treat microorganisms. We believe that our work illustrates the exciting opportunities that nanotechnology offers for alternative antimicrobial strategies and other applications in microbiology.
Monodispersed superparamagnetic nickel colloidal nanocrystal clusters synthesized by pyrolysis can capture bacteria and bacterial spores and simultaneously exert antimicrobial activity.