A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5)

• Published in: Bioorganic & medicinal chemistry letters Vol. 16; no. 18; pp. 4792 - 4795
• Main Authors: Bach, Peter, Nilsson, Karolina, Wållberg, Andreas, Bauer, Udo, Hammerland, Lance G., Peterson, Alecia, Svensson, Tor, Österlund, Krister, Karis, David, Boije, Maria, Wensbo, David
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15-09-2006; Elsevier
• Subjects: Alkynes - chemical synthesis; Alkynes - chemistry; Alkynes - pharmacology; Biological and medical sciences; Glutamatergic system (aspartate and other excitatory aminoacids); Inhibitory Concentration 50; Medical sciences; mGluR5 antagonists; Molecular Structure; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Propargyl ethers; Pyridines - chemistry; Pyridinyl-alkynes; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Receptors, Metabotropic Glutamate - metabolism; SAR; Structure-Activity Relationship; Pyridinyl-alkynes; Propargyl ethers; mGluR5 antagonists; SAR; Group I mglu glutamate receptor; mglu5 glutamate receptor; Acetylenic compound; Ether; Thiazole derivatives; Propargylic compound; Pyrazine derivatives; Glutamate receptor; In vitro; Pyridine derivatives; Structure activity relation; Metabotropic receptor; Benzenic compound; Antagonist; Chemical synthesis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2006.06.079

Synthesis and some structure–activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.
Synthesis and some structure–activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.