Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: a case series

Abstract Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in th...

Full description

Saved in:

Bibliographic Details
Published in:	General hospital psychiatry Vol. 34; no. 2; pp. 209.e9 - 209.e11
Main Authors:	Chopra, Amit, M.D, Das, Piyush, M.D, Rai, Abhishek, M.B.B.S, Kuppuswamy, Preetha Sharone, M.B.B.S, Li, Xiofan, M.D., Ph.D, Huston, John, M.D, Philbrick, Kemuel, M.D, Sola, Christopher, D.O
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2012
Subjects:	Catatonia Catatonia - etiology Female Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Male Middle Aged Neurotoxicity Neurotoxicity Syndromes - complications Neurotoxicity Syndromes - etiology Organ Transplantation Psychiatry Tacrolimus Tacrolimus - adverse effects Tacrolimus - therapeutic use Tacrolimus Neurotoxicity Catatonia
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in these patients after reducing the tacrolimus dosage or switching it to alternative immunosuppressants. Catatonia symptoms in organ transplant patients should alert clinicians to look for tacrolimus-induced neurotoxicity despite normal serum tacrolimus levels and neuroimaging findings.
ISSN:	0163-8343 1873-7714
DOI:	10.1016/j.genhosppsych.2011.08.008