Does platelet serotonin receptor supersensitivity accompany endogenous depression?

In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.0.04 microM) than that of closely matched controls (0.532 +/...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 25; no. 4; p. 375
Main Authors:	Brusov, O S, Beliaev, B S, Katasonov, A B, Zlobina, G P, Factor, M I, Lideman, R R
Format:	Journal Article
Language:	English
Published:	United States 15-02-1989
Subjects:	Adult Antidepressive Agents - therapeutic use Bipolar Disorder - blood Bipolar Disorder - drug therapy Blood Platelets - drug effects Carbazoles - therapeutic use Depressive Disorder - blood Depressive Disorder - drug therapy Female Humans Imipramine - therapeutic use Male Maprotiline - therapeutic use Middle Aged Platelet Aggregation - drug effects Receptors, Serotonin - drug effects Serotonin - blood
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Summary:	In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.0.04 microM) than that of closely matched controls (0.532 +/- 0.1 microM). This platelet concentration becomes higher after 1-3 months of antidepressant treatment (0.47 +/- 0.16 microM). Possible mechanisms for this up- or down-regulation of platelet serotonin receptor responsiveness are discussed.
ISSN:	0006-3223
DOI:	10.1016/0006-3223(89)90190-X