Antiproliferative and antibacterial potential of tetrahexylammonium bromide-based ionic liquids

• Published in: Experimental and therapeutic medicine Vol. 22; no. 1; p. 672
• Main Authors: Popescu, Roxana, Filimon, Marioara Nicoleta, Vlad, Daliborca Cristina, Verdes, Doina, Moatar, Aurica, Moise, Georgiana, Guran, Kristine, Caraba, Ion Valeriu, Ciochina, Liliana Petculescu, Pinzaru, Iulia, Dehelean, Cristina Adriana, Dumitrescu, Gabi
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01-07-2021; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; Cancer; Care and treatment; Cell culture; Cytotoxicity; E coli; Gram-positive bacteria; Health aspects; Investigations; Ionic liquids; Microorganisms; Pharmacology, Experimental; Salmonella; Streptococcus infections; Romania; antibacterial; ionic liquids; antiproliferative; tetrahexylammonium bromide-based ionic liquid
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2021.10104

Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide-based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram-positive and Gram-negative bacteria were conducted by employing Disk-Diffusion and 2,3,5-triphenyltetrazolium chlorine (TTC) methods to assess the antimicrobial effects. Likewise, the antitumor effects on 2D and 3D cell culture systems were assessed using the human colon cancer Caco-2 cell line and cytotoxic activity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Alamar blue assays. Results obtained showed that [CH
(CH
)
]
N(Br) possesses an antibacterial potential, particularly in the case of two bacteria,
(Gram
) and
(Gram
)
Preliminary screening of antiproliferative activity showed moderate activity, except for the concentration of 10 mM. Furthermore, regarding the effect of [CH
(CH
)
]
N(Br) on tumor cell aggregation, positive outcomes were noted. [CH
(CH
)
]
N(Br) presents promising and under-explored potential to improve antibacterial or anticancer therapies.