Synthesis and screening of bicyclic carbohydrate-based compounds: A novel type of antivirals

A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure–activity relationship for this new type of antivirals is discussed. A small library of bicyclic carbohydrate derivatives was synthesized and...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 16; no. 6; pp. 1495 - 1498
Main Authors:	Hoof, Steven Van, Ruttens, Bart, Hubrecht, Idzi, Smans, Gert, Blom, Petra, Sas, Benedikt, Van hemel, Johan, Vandenkerckhove, Jan, Van der Eycken, Johan
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 15-03-2006 Elsevier
Subjects:	Anti-CMV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - pharmacology Carbohydrates Carbohydrates - chemical synthesis Carbohydrates - chemistry Carbohydrates - pharmacology Cells, Cultured - drug effects Cytomegalovirus Cytomegalovirus - pathogenicity Cytomegalovirus Infections - drug therapy Cytomegalovirus Infections - virology Humans Lung - drug effects Lung - embryology Lung - virology Medical sciences Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship Anti-CMV Carbohydrates Cytomegalovirus Antiviral Herpesviridae Selectivity Oxygen heterocycle Betaherpesvirinae In vitro Human cytomegalovirus Virus Structure activity relation Chemical compound library Bicyclic compound C-Glycoside Chemical synthesis
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Summary:	A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure–activity relationship for this new type of antivirals is discussed. A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure–activity relationship for this new type of antivirals is discussed.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.12.048