Synergistic Mechano-Chemical Sensing by Vascular Cilia

Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP sign...

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Bibliographic Details
Published in:	Trends in cell biology Vol. 28; no. 7; pp. 507 - 508
Main Authors:	Follain, Gautier, Goetz, Jacky G.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2018 Elsevier BV
Subjects:	Biochemistry, Molecular Biology Biology Blood flow Blood vessels Bone morphogenetic proteins Cells Chemical perception Chemoreception Cilia Endothelial cells Life Sciences Organic chemistry Retina Sensitivity Vascular endothelial growth factor
Online Access:	Get full text
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Summary:	Endothelial cells can sense and respond to blood flow forces and signals, but the exact mechanisms employed remain poorly understood. A recent study describes how low-flow forces are sensed by primary cilia during development of the retinal vasculature, which sensitizes endothelial cells to BMP signaling.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	0962-8924 1879-3088 0962-8924
DOI:	10.1016/j.tcb.2018.04.005