Particle Size Distributions in Mesh Cuts and Microscopically Estimated Volumetric Shape Factors

• Published in: Drug development and industrial pharmacy Vol. 25; no. 3; pp. 347 - 352
• Main Authors: Carstensen, J. T., Dali, Mandar
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 01-01-1999; Taylor & Francis
• Subjects: Algorithms; Analysis; Biological and medical sciences; Chemical Phenomena; Chemistry, Physical; Crystallization; General pharmacology; Image Processing, Computer-Assisted; Medical sciences; Oxalic Acid - chemistry; Particle Size; Pharmaceutical Preparations - chemistry; Pharmacology. Drug treatments; Phthalimides - chemistry; Salicylic Acid - chemistry; Software; Drug; Sieving; Methodology; Physical properties; Powder; Image analysis; Particle size distribution; Optical microscopy; Qualitative analysis; Mathematical model; Computer aid; Form factor; Physicochemical properties
• ISSN: 0363-9045; 1520-5762
• DOI: 10.1081/DDC-100102180

When particle size distribution parameters are calculated from sieve analysis, it is generally assumed that the distribution within the particle cut is either linear, producing a mean particle size equal to the average of the mesh openings 1-3, or that a more proper number is the geometric mean of these two apertures. It is shown here that particles within a mesh cut are not linearly distributed, but rather may be normally, log-normally, or biphasic combinations of the two. Three compounds were examined in this fashion, and results are reported here.