A minimally invasive approach for peritonectomy procedures and hyperthermic intraperitoneal chemotherapy (HIPEC) in limited peritoneal carcinomatosis: The American Society of Peritoneal Surface Malignancies (ASPSM) multi-institution analysis

• Published in: Surgical endoscopy Vol. 33; no. 3; pp. 854 - 860
• Main Authors: Arjona-Sanchez, A., Esquivel, J., Glehen, O., Passot, G., Turaga, K. K., Labow, D., Rufian-Peña, S., Morales, R., van der Speeten, K.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-03-2019; Springer Nature B.V
• Subjects: Abdominal Surgery; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cytoreduction Surgical Procedures - methods; Female; Gastric cancer; Gastroenterology; Gynecology; Hepatology; Humans; Hyperthermia, Induced - adverse effects; Hyperthermia, Induced - methods; Laparoscopy - adverse effects; Laparoscopy - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Morbidity; Mortality; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Outcome and Process Assessment, Health Care; Peritoneal Neoplasms - drug therapy; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - surgery; Postoperative Complications - epidemiology; Proctology; Reoperation - methods; Reoperation - statistics & numerical data; Retrospective Studies; Surgery; Laparoscopic surgery; Cytoreductive surgery (CRS); Hyperthermic intraperitoneal chemotherapy (HIPEC)
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-018-6352-4

Background
Minimally invasive surgery is playing an increasing role in the treatment of patients with gastrointestinal and gynaecological malignancies as the data show reduced morbidity, faster recovery and similar oncological outcome when compared to open procedures.
Materials and methods
The American Society of Peritoneal Surface Malignancies (ASPSM) conducted a retrospective study to analyse peritonectomy procedures and HIPEC done via the laparoscopic route. A database with standard clinical and pathological parameters was set up and distributed amongst ASPSM members. Rate of relapse, morbidity and mortality were the primary endpoints of the study.
Results
A total of 90 patients from 7 centres around the world were identified. Sixty percent were female. Mean age was 50 years. Peritoneal carcinomatosis from appendiceal origin was the most common diagnosis in a 64.9% of patients and colon origin was diagnosed in 16.5% of patients. Mean peritoneal cancer index (PCI) was 4.1 (0–10). Forty-one percent of patients had a bowel resection. Mean operative time was 4.7 h (2.5–8). All patients had a complete cytoreduction and HIPEC. Grade 3 and 4 morbidity was 3.0 and 6.5%, respectively. The most common reason for re-operation was an internal hernia in 2 out of 5 cases. Operative mortality and re-admission rates were 0 and 5%, respectively. Mean hospital stay was 7.4 days (1–18). At a mean follow-up of 31.6 months, 15/90 patients have a disease relapse but loco-regional relapse was identified in only five patients.
Conclusions
Analysis of these data suggests that minimally invasive approach for peritonectomy procedures and HIPEC is feasible, safe and should be considered as part of the armamentarium for highly selected patients with peritoneal surface malignancies with limited tumour burden, defined as PCI of 10 or less and borderline tumours as low-grade pseudomyxoma and benign multicystic mesothelioma.