Prognostic significance of troponin increment after percutaneous coronary intervention: A retrospective study

• Published in: Frontiers in cardiovascular medicine Vol. 9; p. 833522
• Main Authors: Li, Ya, Li, Duanbin, Zhao, Liding, Xu, Tian, Lv, Qingbo, He, Jialin, Wang, Yao, Zhang, Wenbin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30-08-2022
• Subjects: Cardiovascular Medicine; coronary artery disease; percutaneous coronary intervention; periprocedural myocardial infarction; retrospective study; troponin; coronary artery disease; periprocedural myocardial infarction; percutaneous coronary intervention; troponin; retrospective study
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2022.833522

The prognostic significance of troponin elevation following percutaneous coronary intervention (PCI) remains debated. This study aimed to evaluate the association between different thresholds of post-PCI cardiac troponin I (cTnI) and mortality.
From January 2012 to July 2017, 5,218 consecutive patients undergoing elective PCI with pre-PCI cTnI < 99th percentile of the upper reference limit (URL) were included. Levels of cTnI were measured before PCI and every 8 h for 24 h after procedural. The outcomes were 3-year cardiac mortality.
Patients had a mean age of 66.2 years, 27.6% were women, 67.0% had hypertension, and 26.2% had diabetes mellitus. During the 3 years of follow-up, cardiac death occurred in 0.86%, 1.46%, 1.69%, 2.36%, and 2.86% of patients with cTnI < 1, ≥ 1 to < 5, ≥ 5 to < 35, ≥ 35 to < 70, and ≥ 70 times URL. The cardiac mortality rate was moderately increased with higher peak cTnI values, but the Kaplan-Meier curve demonstrated no significant association between any increment of cTnI and either cardiac or non-cardiac mortality. Isolated cTnI increment of ≥ 5 × URL, ≥ 35 × URL, and ≥ 70 × URL was occurred in 1,379 (26.4%), 197 (3.8%), and 70 (1.3%) patients, respectively. In multivariate Cox regression analysis and Fine-Gray model, none of the above cTnI thresholds was significantly associated with an increased risk of cardiac death.
In patients who underwent elective PCI, post-PCI cTnI elevation is not independently associated with cardiac mortality.