Neural bases of congenital amusia in tonal language speakers

• Published in: Neuropsychologia Vol. 97; pp. 18 - 28
• Main Authors: Zhang, Caicai, Peng, Gang, Shao, Jing, Wang, William S.-Y.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-03-2017
• Subjects: Adolescent; Adult; Auditory Perceptual Disorders - physiopathology; Brain - physiopathology; Cantonese; Congenital amusia; Female; fMRI; Hong Kong; Humans; Language; Lexical tone; Magnetic Resonance Imaging; Male; Music; Neural bases; Speech Perception - physiology; Young Adult; fMRI; Congenital amusia; Neural bases; Lexical tone; Music; Cantonese
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2017.01.033

Congenital amusia is a lifelong neurodevelopmental disorder of fine-grained pitch processing. In this fMRI study, we examined the neural bases of congenial amusia in speakers of a tonal language – Cantonese. Previous studies on non-tonal language speakers suggest that the neural deficits of congenital amusia lie in the music-selective neural circuitry in the right inferior frontal gyrus (IFG). However, it is unclear whether this finding can generalize to congenital amusics in tonal languages. Tonal language experience has been reported to shape the neural processing of pitch, which raises the question of how tonal language experience affects the neural bases of congenital amusia. To investigate this question, we examined the neural circuitries sub-serving the processing of relative pitch interval in pitch-matched Cantonese level tone and musical stimuli in 11 Cantonese-speaking amusics and 11 musically intact controls. Cantonese-speaking amusics exhibited abnormal brain activities in a widely distributed neural network during the processing of lexical tone and musical stimuli. Whereas the controls exhibited significant activation in the right superior temporal gyrus (STG) in the lexical tone condition and in the cerebellum regardless of the lexical tone and music conditions, no activation was found in the amusics in those regions, which likely reflects a dysfunctional neural mechanism of relative pitch processing in the amusics. Furthermore, the amusics showed abnormally strong activation of the right middle frontal gyrus and precuneus when the pitch stimuli were repeated, which presumably reflect deficits of attending to repeated pitch stimuli or encoding them into working memory. No significant group difference was found in the right IFG in either the whole-brain analysis or region-of-interest analysis. These findings imply that the neural deficits in tonal language speakers might differ from those in non-tonal language speakers, and overlap partly with the neural circuitries of lexical tone processing (e.g. right STG).
•Cantonese amusics show abnormal neural activities in a widely distributed network;•Relative pitch processing deficit in right superior temporal gyrus and cerebellum;•Working memory and/or attention deficit in right middle frontal gyrus and precuneus;•Neural bases of Cantonese amusics partly overlap with brain network of lexical tone;•Neural bases of amusia in tonal languages differ from those in non-tonal languages.