Synthesis of N-aryl-N'-heteroaryl-substituted urea and thiourea derivatives and evaluation of their anticonvulsant activity

Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were fou...

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Bibliographic Details
Published in:	Archiv der Pharmazie (Weinheim) Vol. 330; no. 7; p. 207
Main Authors:	Heinisch, G, Matuszczak, B, Rakowitz, D, Tantisira, B
Format:	Journal Article
Language:	English
Published:	Germany 01-07-1997
Subjects:	Animals Anticonvulsants - chemical synthesis Anticonvulsants - pharmacology Male Mice Structure-Activity Relationship Thiourea - analogs & derivatives Thiourea - chemical synthesis Thiourea - pharmacology Urea - analogs & derivatives Urea - chemical synthesis Urea - pharmacology
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Summary:	Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were found to be convulsants per se.
ISSN:	0365-6233
DOI:	10.1002/ardp.19973300704