Effects of estrogenic chemicals on development

The sum of the evidence supports the necessity to continue to investigate the developmental effects of estrogenic and antiestrogenic compounds when exposure occurs early in life. Additional studies will answer questions relevant to the molecular definition of the developmental or carcinogenic effect...

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Bibliographic Details
Published in:	Environmental health perspectives Vol. 103 Suppl 7; no. Suppl 7; pp. 63 - 67
Main Authors:	Jones, L A, Hajek, R A
Format:	Journal Article
Language:	English
Published:	United States 01-10-1995
Subjects:	Alterations Animals Animals, Newborn Carcinogens Carcinogens, Environmental - adverse effects Cells, Cultured Chromosome Aberrations - chemically induced Chromosome Disorders Embryonic and Fetal Development - drug effects Estrogens Estrogens - toxicity Female Genes Health Humans Male Mice Muscle Development Muscles - drug effects
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Summary:	The sum of the evidence supports the necessity to continue to investigate the developmental effects of estrogenic and antiestrogenic compounds when exposure occurs early in life. Additional studies will answer questions relevant to the molecular definition of the developmental or carcinogenic effects of estrogens such as hormone-induced gene alterations. These studies also support the need to use the neonatal mouse model to demonstrate the consequences of reproductive and nonreproductive stem-cell exposure to estrogenic compounds.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0091-6765 1552-9924
DOI:	10.1289/ehp.95103s763