Evaluation of serum levels of IL-9 and IL-17 in human Schistosoma mansoni infection and their relationship with periportal fibrosis

• Published in: Immunobiology (1979) Vol. 221; no. 12; pp. 1351 - 1354
• Main Authors: Barreto, Ana Virgínia Matos Sá, Lacerda, Glaucia Alyne Nunes de, Figueiredo, Anna Lígia de Castro, Diniz, George Tadeu Nunes, Gomes, Elainne Christine Souza, Domingues, Ana Lúcia Coutinho, Barbosa, Constança Simões, Montengro, Silvia Maria Lucena, Morais, Clarice Neuenschwander Lins de
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier GmbH 01-12-2016
• Subjects: Acute Disease; Adolescent; Adult; Advanced Basic Science; Allergy and Immunology; Animals; Brazil; Child; Evaluation; Female; Humans; Interleukin-17; Interleukin-17 - blood; Interleukin-9; Interleukin-9 - blood; Liver Cirrhosis - immunology; Male; Schistosoma mansoni - immunology; Schistosomiasis mansoni; Schistosomiasis mansoni - immunology; Young Adult; Schistosomiasis mansoni; Evaluation; Interleukin-9; Interleukin-17
• ISSN: 0171-2985; 1878-3279
• DOI: 10.1016/j.imbio.2016.07.014

Abstract Serum levels of IL-9 and IL-17 cytokines were evaluated in patients in the acute, chronic phases and clinical forms of human schistosomiasis and in different classifications of periportal fibrosis. No significant differences between the groups of the disease with serum levels of cytokine were found. However, this study discusses the results of some cytokines that have not fully defined roles in the pathology of human schistosomiasis. Furthermore, an examination was made of subjects in the acute phase. This is an important group that is difficult to identify in areas where the disease is endemic. More studies are being undertaken to study the role of IL-9 and IL-17 in human Schistosoma mansoni infection and their relationship with the immunopathogenesis of disease.