Effect of surgical staging on 539 patients with borderline ovarian tumors: A Turkish Gynecologic Oncology Group study

• Published in: Gynecologic oncology Vol. 131; no. 3; pp. 546 - 550
• Main Authors: Guvenal, Tevfik, Dursun, Polat, Hasdemir, Pinar S, Hanhan, Merih, Guven, Suleyman, Yetimalar, Hakan, Goksedef, Behice P, Sakarya, Derya K, Doruk, Arzu, Terek, Mustafa C, Saatli, Bahadir, Guzin, Kadir, Corakci, Aydin, Deger, Emek, Celik, Husnu, Cetin, Ahmet, Ozsaran, Aydin, Ozbakkaloglu, Ayşe, Kolusari, Ali, Celik, Cetin, Keles, Refik, Sagir, Fulya G, Dilek, Saffet, Uslu, Turhan, Dikmen, Yilmaz, Altundag, Ozden, Ayhan, Ali
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2013
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Appendectomy; Borderline; Female; Hematology, Oncology and Palliative Medicine; Humans; Kaplan-Meier Estimate; Lymph Node Excision; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphadenectomy; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Obstetrics and Gynecology; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Ovarian tumor; Retrospective Studies; Surgical staging; Turkey - epidemiology; Young Adult; Turkey; Lymphadenectomy; Appendectomy; Borderline; Surgical staging; Ovarian tumor
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2013.08.038

Abstract Objective The objectives of this study were to examine demographic and clinicopathologic characteristics and to determine the effects of primary surgery, surgical staging and the extensiveness of staging. Methods In a retrospective Turkish multicenter study, 539 patients, from 14 institutions, with borderline ovarian tumors were investigated. Some of the demographic, clinical and surgical characteristics of the cases were evaluated. The effects of type of surgery, surgical staging; complete or incomplete staging on survival rates were calculated by using Kaplan–Meier method. Results The median age at diagnosis was 40 years (range 15–84) and 71.1% of patients were premenopausal. The most common histologic types were serous and mucinous. Majority of the staged cases were in Stage IA (73.5%). 242 patients underwent conservative surgery. Recurrence rates were significantly higher in conservative surgery group (8.3% vs. 3%). Of all patients in this study, 294 (54.5%) have undergone surgical staging procedures. Of the patients who underwent surgical staging, 228 (77.6%) had comprehensive staging including lymphadenectomy. Appendectomy was performed on 204 (37.8%) of the patients. The median follow-up time was 36 months (range 1–120 months). Five-year survival rate was 100% and median survival time was 120 months. Surgical staging, lymph node sampling or dissection and appendectomy didn't cause any difference on survival. Conclusion Comprehensive surgical staging, lymph node sampling or dissection and appendectomy are not beneficial in borderline ovarian tumors surgical management.