Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model

• Published in: Photodiagnosis and photodynamic therapy Vol. 12; no. 1; pp. 58 - 66
• Main Authors: Baglo, Yan, Ph.D, Peng, Qian, Hagen, Lars, Berg, Kristian, Høgset, Anders, Drabløs, Finn, Gederaas, Odrun A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-03-2015
• Subjects: Animals; Cell Line, Tumor; Disulfonated meso-tetraphenyl chlorin; Female; Hematology, Oncology and Palliative Medicine; Internal Medicine; Metabolic Clearance Rate; Non-muscle invasive bladder cancer; Photochemical internalization; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - pharmacokinetics; Photosensitizing Agents - therapeutic use; Porphyrins - pharmacokinetics; Porphyrins - therapeutic use; Rat orthotopic bladder tumor model; Rats; Rats, Inbred F344; Tissue Distribution; Treatment Outcome; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Non-muscle invasive bladder cancer; Rat orthotopic bladder tumor model; Photodynamic therapy; Disulfonated meso-tetraphenyl chlorin; Photochemical internalization
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2014.12.005

Highlights • Pioneering study of the photosensitizer disulfonated meso-tetraphenyl chlorin in rat bladder tumor model. • Location, distribution and penetration of the photosensitizer in bladder tissue were shown. • Optimal concentration and retention time of the photosensitizer were determined.