Dihydro-resveratrol—A potent dietary polyphenol

• Published in: Bioorganic & medicinal chemistry letters Vol. 20; no. 20; pp. 6149 - 6151
• Main Authors: Gakh, Andrei A., Anisimova, Natalia Yu, Kiselevsky, Mikhail V., Sadovnikov, Sergey V., Stankov, Ivan N., Yudin, Mikhail V., Rufanov, Konstantin A., Krasavin, Mikhail Yu, Sosnov, Andrey V.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15-10-2010
• Subjects: 60 APPLIED LIFE SCIENCES; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; BASIC BIOLOGICAL SCIENCES; Breast cancer; Breast Neoplasms - drug therapy; Cancer; Cell Line, Tumor; Cell Proliferation - drug effects; Dietary Supplements; Dihydro-resveratrol; estrogen receptors; Female; Flavonoids - chemistry; Flavonoids - pharmacology; HORMONES; Humans; MAMMARY GLANDS; NEOPLASMS; Neoplasms, Hormone-Dependent - drug therapy; Phenols - chemistry; Phenols - pharmacology; Phytoestrogen; POLYPHENOLS; Resveratrol; Stilbenes - chemistry; Stilbenes - pharmacology; TUMOR CELLS; Vitaceae; Wine; Phytoestrogen; Dihydro-resveratrol; Cancer
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2010.08.002

Dihydro-resveratrol, a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines at picomolar concentrations.
Dihydro-resveratrol (
dihydro-
R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of
dihydro-
R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562).