Progression of Renal Impairment and Chronic Kidney Disease in Chronic Heart Failure: An Analysis From GISSI-HF

• Published in: Journal of cardiac failure Vol. 23; no. 1; pp. 2 - 9
• Main Authors: Damman, Kevin, MD, PhD, Masson, Serge, PhD, Lucci, Donata, MSc, Gorini, Marco, MS, Urso, Renato, PhD, Maggioni, Aldo P., MD, Tavazzi, Luigi, MD, Tarantini, Luigi, MD, Tognoni, Gianni, MD, Voors, Adriaan, MD, PhD, Latini, Roberto, MD
• Format: Journal Article
• Language: English
• Published: United States 01-01-2017
• Subjects: Aged; Cardiovascular; Creatinine - blood; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Fatty Acids, Omega-3 - administration & dosage; Female; Glomerular Filtration Rate - physiology; Heart Failure - complications; Heart Failure - drug therapy; Heart Failure - physiopathology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Male; Middle Aged; Prognosis; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - physiopathology; Rosuvastatin Calcium - administration & dosage; chronic kidney disease; chronic heart failure; Renal function; prognosis
• ISSN: 1071-9164; 1532-8414
• DOI: 10.1016/j.cardfail.2016.09.006

Highlights • The mean deterioration in estimated GFR in patients with chronic heart failure was 1.5 mL • min−1  • 1.73 m−2 in the first year, which can be considered to be moderate. • A minority of patients (one sixth) experienced a strong decrease in renal function in the 1st year (15 mL • min−1  • 1.73 m−2 ). • Factors associated with progressive decline were baseline renal dysfunction, COPD, and loop diuretic use. • Lower renal function at baseline and any decrease over time was strongly associated with worse clinical outcomes, including cardiovascular death and heart failure hospitalization.