Ciprofloxacin-resistant Escherichia coli from bacteraemias in England; increasingly prevalent and mostly from men

• Published in: Journal of antimicrobial chemotherapy Vol. 52; no. 6; pp. 1040 - 1042
• Main Authors: Livermore, David M., Nichols, Tom, Lamagni, Theresa L., Potz, Nicola, Reynolds, Rosy, Duckworth, Georgia
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-12-2003; Oxford Publishing Limited (England)
• Subjects: Adolescent; Adult; Aged; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; bacteraemia; Bacteremia - epidemiology; Bacteremia - microbiology; Biological and medical sciences; Child; Child, Preschool; Ciprofloxacin - pharmacology; ciprofloxacin resistance; Drug Resistance, Bacterial; E. coli; England - epidemiology; Escherichia coli - drug effects; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Female; gender; Humans; Infant; Male; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Pharmacology. Drug treatments; Religion; Sex Factors; England; United Kingdom; Great Britain; Europe; Human; Escherichia coli; Sex; Male; In vitro; Bacteremia; Infection; Resistance; Fluoroquinolone derivatives; Bacteriosis; Bacteria; Female; Antibacterial agent; Ciprofloxacin; Clinical isolate; Quinolone derivatives; Age; Enterobacteriaceae
• ISSN: 0305-7453; 1460-2091; 1460-2091
• DOI: 10.1093/jac/dkg479

Objectives: To assess ciprofloxacin resistance among Escherichia coli isolates from bacteraemia patients in England in relation to age, sex and Region. Methods: Routine susceptibility data for bacteraemia isolates were collected from over 90% of hospitals in England. Results: During 1995–2001, the prevalence of ciprofloxacin resistance trebled, from 2.1% to 6.5%. Isolates from men were more frequently resistant than those from women, possibly because infections in men more often involve nosocomial strains. Resistance was rare (<1.5%) in isolates from patients aged <1 year; among older patients, resistance was unrelated to age in isolates from women, but peaked in the 15–44 age group for men. Conclusions: The prevalence of ciprofloxacin resistance in E. coli from bacteraemia is strongly associated with sex and, to a lesser extent, age.