Direct Actions of Macronutrient Components on Goldfish Hepatopancreas In Vitro to Modulate the Expression of ghr-I , ghr-II , igf-I and igf-II mRNAs

• Published in: General and comparative endocrinology Vol. 250; pp. 1 - 8
• Main Authors: Bertucci, Juan Ignacio, Blanco, Ayelén Melisa, Canosa, Luis Fabián, Unniappan, Suraj
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2017
• Subjects: Animals; Diet; Endocrinology & Metabolism; Fatty acid; Fatty Acids - pharmacology; Gene Expression Regulation - drug effects; Glucose; Glucose - pharmacology; Goldfish - genetics; Growth hormone receptor; Hepatopancreas - drug effects; Hepatopancreas - metabolism; Insluline-like growth factor; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Insulin-Like Growth Factor II - genetics; Insulin-Like Growth Factor II - metabolism; Metabolism; Receptors, Somatotropin - genetics; Receptors, Somatotropin - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Tryptophan; Tryptophan - pharmacology; Tryptophan; Glucose; Insluline-like growth factor; Metabolism; Growth hormone receptor; Fatty acid
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/j.ygcen.2017.05.014

Highlights • Glucose and tryptophan upregulate the expression of ghr-I; ghr-II; igf-I and igf-II. • Fatty acid’s unsaturation level modulates the ghr-I and ghr-II expression. • Fatty acids increase the igf-I expression and modulate the expression of igf-II. • We report GH-independent, direct effects of macronutrients on GHR and IGF in fish.