Vertical Optokinetic Nystagmus and Saccades in Normal Human Subjects

• Published in: Investigative ophthalmology & visual science Vol. 44; no. 9; pp. 3833 - 3841
• Main Authors: Garbutt, Siobhan, Han, Yanning, Kumar, Arun N, Harwood, Mark, Harris, Chris M, Leigh, R. John
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01-09-2003; Association for Research in Vision and Ophtalmology
• Subjects: Adult; Biological and medical sciences; Eye and associated structures. Visual pathways and centers. Vision; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Medical sciences; Middle Aged; Nystagmus, Optokinetic - physiology; Oculomotor disorders; Ophthalmology; Photic Stimulation; Saccades - physiology; Vertebrates: nervous system and sense organs; Vision, Binocular - physiology; Visual Perception - physiology; Human; Vertical nystagmus; Eye disease; Oculomotor syndrome; Normal; Optokinetic nystagmus
• ISSN: 0146-0404; 1552-5783; 1552-5783
• DOI: 10.1167/iovs.03-0066

Optokinetic stimulation induces nystagmus that can be used to test the saccadic and visual-tracking systems in some patients with voluntary gaze palsies. The purpose of this study was to characterize vertical optokinetic nystagmus (OKN) in normal human subjects, comparing the dynamic properties of the quick phases with voluntary saccades of similar size and measuring the slow-phase responses to visual stimuli with a range of spatial and temporal frequencies.
Vertical OKN and saccades were recorded in 10 healthy adult subjects (age range, 24-54 years) using the magnetic search coil technique. The optokinetic (OK) stimulus subtended 72 degrees horizontally and 60 degrees vertically, consisted of black-and-white stripes with a spatial frequency of 0.04, 0.08, or 0.16 cyc/deg, and moved vertically at 10 to 50 deg/s. Vertical and horizontal saccades to visual targets separated by 1 degrees to 10 degrees were also elicited.
Over 95% of quick phases were less than 10 degrees in amplitude; voluntary saccades of this amplitude range were slightly faster than quick phases of similar size. The amplitude-peak velocity relationships and amplitude-duration relationships of upward and downward fast movements (saccades or quick phases) were similar. Most vertical slow-phase OK responses showed greater gain for upward stimulus motion. OK gain decreased with increasing stimulus speed and increased spatial frequency, so that there was a general decrease in slow-phase velocity gain with increasing temporal frequency.
In this study, the best OK responses were obtained using stripes with lower spatial frequencies and lower stripe speeds (0.4 cyc/deg at 10 deg/s). The dynamic properties of vertical quick phases of nystagmus are similar enough to those of voluntary saccades for OK stimulation to be used as a clinical test of the vertical saccadic system in individuals with voluntary gaze palsy.