Progress in structure, synthesis and biological activity of natural cephalotane diterpenoids

• Published in: Phytochemistry (Oxford) Vol. 192; p. 112939
• Main Authors: Jiang, Chunyu, Xue, Jingjing, Yuan, Yizhen, Li, Yanzhi, Zhao, Chunxue, Jing, Qinxue, Zhang, Xin, Yang, Mengyue, Han, Tong, Bai, Jiao, Li, Zhanlin, Li, Dahong, Hua, Huiming
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-12-2021
• Subjects: Antitumor activity; Cephalotane diterpenoids; Cephalotaxaceae; Structure; Structure–activity relationships; Total synthesis; Antitumor activity; Cephalotaxaceae; Structure; Structure–activity relationships; Cephalotane diterpenoids; Total synthesis
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2021.112939

The Cephalotaxus genus is well-known owing to the numerous complex, biologically relevant natural products that can be obtained from its constituent species. The successful identification of various Cephalotaxus alkaloids and natural, structurally diverse cephalotane diterpenoids that exhibit antitumor activities and excellent pharmacological properties has encouraged the discovery of previously undescribed compounds from this genus. The present review summarizes the different strategies for the total synthesis of cephalotane diterpenoids as well as their diverse chemical structures, antitumor activities, structure–activity relationships (SARs), and biosynthetic pathways.
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•Novel cephalotane diterpenoids are important active components in Cephalotaxus genus.•The chemical structure classification of cephalotane diterpenoids are summarized.•The total synthesis of some cephalotane diterpenoids are summarized.•The pharmacological effects and structure-activity relationships are introduced.