Discrepancies in Lymphoma Diagnosis Over the Years: A 13-Year Experience in a Tertiary Center

• Published in: Turkish journal of haematology Vol. 34; no. 1; pp. 81 - 88
• Main Authors: Özkaya, Neval, Başsüllü, Nuray, Demiroz, Ahu Senem, Tüzüner, Nükhet
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Publishing 01-03-2017; Galenos Publishing House
• Subjects: diagnosis of lymphoma; discrepancies in diagnosis; hematopathology; Humans; Lymphoma - diagnosis; Lymphoma - pathology; Lymphoma, B-Cell - diagnosis; Lymphoma, B-Cell - pathology; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - pathology; Neoplasm Grading; Referral and Consultation; Tertiary Care Centers; world health organization lymphoma classification
• ISSN: 1300-7777; 1308-5263
• DOI: 10.4274/tjh.2016.0344

In the past, accurate diagnosis of lymphoma was challenging since there were multiple competing classification systems that caused confusion and debate. After establishment of the World Health Organization lymphoma classification, lymphomas still remain a diagnostic challenge among general pathologists. The purpose of this study was to examine whether the discordance among centers has declined over the years.
All lymphoma or lymphoma-suspected specimens that had been sent to the Cerrahpaşa Faculty of Medicine between 2000 and 2013 for a second opinion were deemed eligible. To evaluate the change in the discrepancy rates over time we compared the rates of revision between 2000-2008 and 2009-2013.
A total of 1824 patients in two time periods met the inclusion criteria. The overall discordance rate was 45.6%. This rate showed significant variations between different histologic subtypes. Discordance rates also varied significantly over time and decreased from 51.3% in 2000-2008 to 38.7% in 2009-2013 (p<0.0001).
The high discordance rate, especially in the second period, indicates the need for easily accessible hematopathology consultation centers.