Evaluation of electrocardiographic parameters in patients with diabetes insipidus

• Published in: Wiener Klinische Wochenschrift Vol. 127; no. 21-22; pp. 871 - 876
• Main Authors: Deniz, Ferhat, Kepez, Alper, Ay, Seyit Ahmet, Ergogan, Okan, Baskoy, Kamil, Guncıkan, Mustafa Nuri, Dogan, Zekeriya, Yonem, Arif
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-11-2015
• Subjects: Adult; Diabetes Insipidus - diagnosis; Diabetes Insipidus - physiopathology; Electrocardiography - methods; Endocrinology; Female; Gastroenterology; Heart Rate; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Original Article; Pneumology/Respiratory System; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Electrocardiography; Electrolytes; QRS duration; Sodium; Osmolality; Diabetes insipidus
• ISSN: 0043-5325; 1613-7671
• DOI: 10.1007/s00508-015-0874-8

Summary
Background
There is limited data regarding the effect of altered serum osmolality on cardiac electrical activity. The aim of the present study is to evaluate the electrocardiographic (ECG) effects of diabetes insipidus (DI) and any related hyperosmolality in a population of young patients with DI and without any known cardiovascular disease or risk factors.
Methods
Twelve-lead ECG’s of 44 consecutive untreated young male patients (age: 21.8 ± 2.9 years) who had been referred to endocrinology clinic and diagnosed as DI based on water deprivation test were retrospectively evaluated. A total of 30 age-matched (21.9 ± 2.4 years) healthy males were selected as control group and ECG’s of these controls were obtained for comparison with ECG’s of DI patients. All ECG parameters were measured and compared.
Results
Duration of QRS complex was significantly shorter in patients with DI compared with controls (85.2 ± 12.0 vs. 94.0 ± 10.6 ms,
p
: 0.001). P wave dispersion (PWD) of patients with DI was significantly higher compared with controls (31.9 ± 9.9 vs. 26.5 ± 10.6 ms,
p
: 0.03) and it was significantly correlated with serum osmolality and serum sodium level (
r
 = − 0.36,
p
: 0.02 and
r
: − 0.35,
p
: 0.02, respectively).
Conclusions
DI patients without any cardiovascular disease or risk factors displayed significantly shorter QRS duration and increased p wave dispersion compared with controls.