Boosting controlled autoimmunity: a new therapeutic target for CNS disorders

In most tissues, the immune system plays an essential role in protection, repair and healing. Although immunologically privileged, the CNS remains subject to a highly regulated form of immunosurveillance that is of increasing interest. There is evolving evidence that repair mechanisms within the CNS...

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Bibliographic Details
Published in:	Expert review of neurotherapeutics Vol. 8; no. 5; p. 819
Main Authors:	del Barco, Diana García, Berlanga, Jorge, Penton, Eduardo, Hardiman, Orla, Montero, Enrique
Format:	Journal Article
Language:	English
Published:	England 01-05-2008
Subjects:	Animals Autoimmunity - drug effects Autoimmunity - immunology Brain - drug effects Brain - immunology Brain Diseases - immunology Brain Diseases - prevention & control Drug Delivery Systems - methods Humans Models, Immunological Neuroprotective Agents - immunology Neuroprotective Agents - therapeutic use
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Summary:	In most tissues, the immune system plays an essential role in protection, repair and healing. Although immunologically privileged, the CNS remains subject to a highly regulated form of immunosurveillance that is of increasing interest. There is evolving evidence that repair mechanisms within the CNS may be enhanced by exploiting an innate process of protective immunity. Understanding the regulation of protective autoimmunity within the CNS is likely to lead to novel therapeutic approaches to neuroinflammatory and neurodegenerative diseases.
ISSN:	1744-8360
DOI:	10.1586/14737175.8.5.819