N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction

• Published in: Journal of cardiovascular translational research Vol. 8; no. 5; pp. 328 - 337
• Main Authors: Phaelante, Amanda, Rohde, Luís Eduardo, Lopes, Amanda, Olsen, Virgílio, Tobar, Santiago Alonso Leitão, Cohen, Carolina, Martinelli, Nidiane, Biolo, Andréia, Dal-Pizzol, Felipe, Clausell, Nadine, Andrades, Michael
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2015
• Subjects: Acetylcysteine - administration & dosage; Aldehydes; Animals; Antioxidants - administration & dosage; Biomedical Engineering and Bioengineering; Biomedicine; Cardiology; Deferoxamine - administration & dosage; Echocardiography; Human Genetics; Immunohistochemistry; Iron - blood; Iron Chelating Agents - administration & dosage; Male; Medicine; Medicine & Public Health; Myocardial Infarction - drug therapy; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardium - pathology; Oxidative Stress - physiology; Random Allocation; Rats; Rats, Wistar; Stroke Volume - physiology; Sulfhydryl Compounds - blood; Troponin I - blood; Ventricular Function - drug effects; Heart failure; Myocardial infarction; Oxidative stress; N-acetylcysteine; Deferoxamine
• ISSN: 1937-5387; 1937-5395
• DOI: 10.1007/s12265-015-9633-5

The antioxidant N-acetycysteine can turn into a prooxidant molecule in presence of iron ions. Thus, our goal was to test if the association of N-acetylcysteine (NAC) and an iron chelator (deferoxamine—DFX) in a rodent model of acute myocardial infarction (AMI) improves cardiac function. Male Wistar rats were subjected to a SHAM surgery or AMI. The animals were randomized: vehicle, NAC (25 mg/kg for 28 days), DFX (40 mg/kg for 7 days), or NAC plus DFX (NAC plus DFX, respectively). Animals were killed 28 days after the AMI. Animals treated with NAC/DFX showed an increase in left ventricular ejection fraction at 28 days when compared with vehicle group (45.2 ± 10.9 % vs. 34.7 ± 8.7 %,
p
 = 0.03). Antioxidant effect of NAC/DFX treatment decreased 4-hydroxynonenal when compared to AMI group (
p
 = 0.06). In conclusion, we showed beneficial effect of NAC/DFX association in improving left ventricle function in an experimental AMI.