Treatment of oral manifestations of toxic epidermal necrolysis with low‐level laser therapy in a pediatric patient

• Published in: Pediatric dermatology Vol. 36; no. 1; pp. e27 - e30
• Main Authors: Rocha, Amanda Leal, Souza, Alessandra Figueiredo De, Nunes, Laiz Fernandes Mendes, Cunha, Nayara Dias de Souza, Lanza, Célia Regina Moreira, Travassos, Denise Vieira, Silva, Tarcília Aparecida da
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-01-2019
• Subjects: Allergies; Antibiotics; Case reports; Drug therapy; Hypersensitivity; Light therapy; low‐level light therapy; Morbidity; Oral cavity; Oral hygiene; oral manifestations; Patients; Pediatrics; Quality of life; Side effects; Skin diseases; Toxic epidermal necrolysis; low-level light therapy; oral manifestations; toxic epidermal necrolysis
• ISSN: 0736-8046; 1525-1470
• DOI: 10.1111/pde.13719

Drug‐induced reactions are complications associated with high mortality and significant morbidity. Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9‐year‐old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. A drug‐induced hypersensitivity reaction to antibiotics was suspected, and a diagnosis of TEN was made. The patient was managed with withdrawal of the suspected causative agent, and the oral lesions were treated with low‐level laser therapy (LLLT) and oral hygiene. This case highlights that TEN requires interdisciplinary intervention with dental assistance and follow‐up to improve symptoms, nutrition, systemic condition, and quality of life.