In Vitro Activity of Linezolid against Mycobacterium tuberculosis Strains Isoalted from Western Turkey

• Published in: Japanese Journal of Infectious Diseases Vol. 62; no. 5; pp. 384 - 385
• Main Authors: Ermertcan, Şafak, Hoşgör-Limoncu, Mine, Eraç, Bayrı, Taşlı, Hüseyin, Çavuşoğlu, Cengiz, Bozkurt, Hale
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases 30-09-2009
• Subjects: Acetamides - pharmacology; Antitubercular Agents - pharmacology; Hospitals; Humans; Linezolid; Microbial Sensitivity Tests - methods; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - isolation & purification; Oxazolidinones - pharmacology; Tuberculosis - microbiology; Turkey; Turkey
• ISSN: 1344-6304; 1884-2836
• DOI: 10.7883/yoken.JJID.2009.384

We investigated the linezolid susceptibility of Mycobacterium tuberculosis strains isolated from a tertiary care hospital in Izmir. A total of 67 M. tuberculosis strains (33 multidrug-resistant [MDR] and 34 non-MDR) were isolated and identified by the Tuberculosis Laboratory, Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Ege University. The activity of linezolid was studied by the standard agar proportion method. For all of the strains, the MIC range was 0.06-1 mg/L, and the MIC50 and MIC90 values were 0.5 mg/L. No differences were observed between the MDR and non-MDR isolates. In general, linezolid was found to be effective for both the non-MDR and MDR M. tuberculosis strains.