Memory of chirality in reactions involving monoradicals

Memory of chirality in reactions involving monoradicals

The effects of memory of chirality (MoC) in reactions involving monoradical species are reviewed here. Reactions involving a nonracemic chiral starting material bearing a single stereogenic element such as a chiral center or chiral axis directly involved in the new bond formation are discussed. Thes...

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Bibliographic Details
Published in:Free radical research Vol. 50; no. sup1; p. S102
Main Authors: Gloor, Christian Simon, Dénès, Fabrice, Renaud, Philippe
Format: Journal Article
Language:English
Published: England 01-11-2016
Subjects:
Chimerism
Free Radicals
Molecular Structure
Stereoisomerism
atropisomers
Free radicals
asymmetric synthesis
chirality
stereochemistry
conformation
racemization
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Summary:The effects of memory of chirality (MoC) in reactions involving monoradical species are reviewed here. Reactions involving a nonracemic chiral starting material bearing a single stereogenic element such as a chiral center or chiral axis directly involved in the new bond formation are discussed. These reactions lead to a nonracemic product via an intermediate susceptible to rapid racemization. Memory of chirality has been observed in cyclic radicals, aryl, ester/amide substituted acyclic radicals, and benzylic radicals at temperatures up to 130 °C.
ISSN:1029-2470
DOI:10.1080/10715762.2016.1232485