Hospital Readmissions in Patients With Carbapenem-Resistant Klebsiella pneumoniae

• Published in: Infection control and hospital epidemiology Vol. 37; no. 3; pp. 281 - 288
• Main Authors: Messina, Julia A., Cober, Eric, Richter, Sandra S., Perez, Federico, Salata, Robert A., Kalayjian, Robert C., Watkins, Richard R., Scalera, Nikole M., Doi, Yohei, Kaye, Keith S., Evans, Scott, Bonomo, Robert A., Fowler, Vance G., van Duin, David
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01-03-2016
• Subjects: Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Antibiotics; beta-Lactam Resistance; Case-Control Studies; Chronic obstructive pulmonary disease; Comorbidity; Creatinine; Cross Infection - drug therapy; Female; Hospitalization; Humans; Infections; Kaplan-Meier Estimate; Kidney diseases; Klebsiella Infections - drug therapy; Klebsiella pneumoniae - drug effects; Laboratories; Length of stay; Logistic Models; Long term health care; Longitudinal Studies; Male; Microbial Sensitivity Tests; Middle Aged; Minocycline - analogs & derivatives; Minocycline - therapeutic use; Multivariate Analysis; Nursing; Odds Ratio; Original Articles; Patient Readmission - statistics & numerical data; Patients; Prospective Studies; Risk Factors; United States; Variables; United States > US; Great Lakes area
• ISSN: 0899-823X; 1559-6834
• DOI: 10.1017/ice.2015.298

Various transmission routes contribute to spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitalized patients. Patients with readmissions during which CRKP is again isolated ("CRKP readmission") potentially contribute to transmission of CRKP.
To evaluate CRKP readmissions in the Consortium on Resistance against Carbapenems in K. pneumoniae (CRaCKLe).
Cohort study from December 24, 2011, through July 1, 2013.
Multicenter consortium of acute care hospitals in the Great Lakes region.
All patients who were discharged alive during the study period were included. Each patient was included only once at the time of the first CRKP-positive culture.
All readmissions within 90 days of discharge from the index hospitalization during which CRKP was again found were analyzed. Risk factors for CRKP readmission were evaluated in multivariable models.
Fifty-six (20%) of 287 patients who were discharged alive had a CRKP readmission. History of malignancy was associated with CRKP readmission (adjusted odds ratio [adjusted OR], 3.00 [95% CI, 1.32-6.65], P<.01). During the index hospitalization, 160 patients (56%) received antibiotic treatment against CRKP; the choice of regimen was associated with CRKP readmission (P=.02). Receipt of tigecycline-based therapy (adjusted OR, 5.13 [95% CI, 1.72-17.44], using aminoglycoside-based therapy as a reference in those treated with anti-CRKP antibiotics) was associated with CRKP readmission.
Hospitalized patients with CRKP-specifically those with a history of malignancy-are at high risk of readmission with recurrent CRKP infection or colonization. Treatment during the index hospitalization with a tigecycline-based regimen increases this risk.