The complexities of dystroglycan

The notion of dystroglycan as a simple laminin-binding receptor is increasingly being challenged. New roles and new binding partners are continually emerging. Recent structural advances have provided exciting new insights into the precise molecular interactions between dystroglycan and other key com...

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Bibliographic Details
Published in:	Trends in Biochemical Sciences Vol. 26; no. 2; pp. 118 - 124
Main Author:	Winder, Steven J
Format:	Book Review Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2001
Subjects:	Animals Cell Adhesion Cell Division Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - physiology Cytoskeleton - metabolism Dystroglycans Laminin - chemistry Membrane Glycoproteins - chemistry Membrane Glycoproteins - physiology Models, Molecular Protein Binding Protein Structure, Tertiary Signal Transduction
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Summary:	The notion of dystroglycan as a simple laminin-binding receptor is increasingly being challenged. New roles and new binding partners are continually emerging. Recent structural advances have provided exciting new insights into the precise molecular interactions between dystroglycan and other key components of the dystroglycan complex. Coupled with an increasing understanding of dystroglycan function at the molecular level, we are finally beginning to probe the complexities of dystroglycan, not only in disease, but in development, adhesion and signalling.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(00)01731-X