Interactions of Intercellular Adhesion Molecule-1 with Fibrinogen

• Published in: Trends in Cardiovascular Medicine Vol. 12; no. 3; pp. 101 - 108
• Main Authors: Tsakadze, Nina L, Zhao, Zhendong, D'Souza, Stanley E
• Format: Book Review Journal Article
• Language: English
• Published: United States Elsevier Inc 01-04-2002
• Subjects: Animals; Cardiovascular Diseases - metabolism; Endothelium, Vascular - metabolism; Fibrinogen - chemistry; Fibrinogen - metabolism; Humans; Intercellular Adhesion Molecule-1 - biosynthesis; Intercellular Adhesion Molecule-1 - chemistry; Intercellular Adhesion Molecule-1 - metabolism; Models, Molecular; Phosphorylation; Protein Binding; Signal Transduction
• ISSN: 1050-1738; 1873-2615
• DOI: 10.1016/S1050-1738(01)00157-8

The binding of plasma protein fibrinogen (Fg) to intercellular adhesion molecule-1 (ICAM-1) on endothelial cells mediates the attachment of leukocytes and platelets that may result in vascular occlusion. Fg:ICAM-1 interactions elicit an array of effects that could have implications in vascular pathology and inflammation. ICAM-1 expression is regulated during inflammation and upon Fg binding. The mechanistic model presented provides a framework to delineate the consequences of Fg binding to ICAM-1.