Effects of isosorbide dinitrate and nicardipine hydrochloride on postprandial blood pressure in elderly patients with stable angina pectoris or healed myocardial infarction

• Published in: The American journal of cardiology Vol. 75; no. 4; pp. 291 - 293
• Main Authors: Connelly, Carolyn M., Waksmonski, Carol, Gagnon, Margaret M., Lipsitz, Lewis A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-02-1995; Elsevier; Elsevier Limited
• Subjects: Aged; Angina Pectoris - drug therapy; Antianginal agents. Coronary vasodilator agents; Biological and medical sciences; Blood pressure; Blood Pressure - drug effects; Cardiovascular disease; Cardiovascular system; Coronary vessels; Cross-Over Studies; Double-Blind Method; Drug therapy; Eating - physiology; Female; Humans; Hypotension - etiology; Hypotension - physiopathology; Isosorbide Dinitrate - therapeutic use; Male; Medical research; Medical sciences; Myocardial Infarction - drug therapy; Nicardipine - therapeutic use; Older people; Pharmacology. Drug treatments; Human; Coronary vasodilator agent; Postprandial; Toxicity; Cardiovascular disease; Exploration; Angina pectoris; Coronary heart disease; Chemotherapy; Treatment; Arterial hypotension; Arterial pressure; Elderly; Comparative study
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/0002-9149(95)80041-P

The idea that calcium antagonists would have less of an effect on postprandial blood pressure reduction than nitrates in elderly patients with coronary artery disease and diastolic dysfunction was investigated. Most elderly patients with impaired diastolic function can be treated safely with nicardipine for coronary artery disease.