The chemistry and biological activities of Citrus clementina Hort. Ex Tanaka (Rutaceae), a vegetatively propagated species

• Published in: Natural product research Vol. 35; no. 22; pp. 4839 - 4842
• Main Authors: Bissim, Samuel Magloire, Kenmogne, Sidonie Beatrice, Lobe, Jules Songue, Atangana, Albert Fouda, Bissoue, Achile Nouga, Langat, Moses K., Isyaka, Sani M., Lateef, Mehreen, Emmanuel, Ngeufa Happi, Wansi, Jean Duplex, Ali, Muhammad Shaiq, Waffo, Alain François Kamdem
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18-11-2021
• Subjects: acridone; anti-diabetic activity; anti-inflammatory; antioxidant activity; Citrus clementina; urease inhibition; xanthyletin; Citrus clementina; acridone; urease inhibition; anti-inflammatory; xanthyletin; anti-diabetic activity; antioxidant activity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2020.1731740

We report the chemistry and biological activities of a Cameroonian Citrus clementina Hort. Ex Tanaka, a vegetatively propagated species. The compounds isolated from this plant were determined to be the known 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (1), tangerine (3), nobilletin (4), 5,7,8,4'-tetramethoxyflavone (5), citracridone I (6), 5-hydroxynoracronycine (7), citracridone III (8), xanthyletin (10), suberosin (9), E-suberenol (11), E-methoxysuberenol (13), 6-formylumbelliferone (12), aurantiamide acetate (2), limonin (14), stigmasterol, β-sitosterol and β-sitosterol-3-O-β-D-glucoside. The structures of the compounds were established on the basis of their NMR spectroscopic data and comparison with published data. Methanol leaf extract and compounds 1, 2, 4, 6, 7 and 10 were evaluated for their anti-inflammatory, antioxidant, urease and anti-diabetic effects. Compound 10 showed antioxidant activity, anti-inflammatory effect, urease activity and anti-diabetic activity with IC
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values of 47.3 µM, 33.5 µM, 25.2 µM and 33.9 µM respectively, values that were comparable to the respective positive standards.