Kinetics of myosin node aggregation into a contractile ring

Kinetics of myosin node aggregation into a contractile ring

We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that bands of nodes condense into rings when the range of node interactions is larger than the width of the band. Wide bands are unstable to clump...

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Published in:Physical review letters Vol. 105; no. 4; p. 048102
Main Authors: Ojkic, Nikola, Vavylonis, Dimitrios
Format: Journal Article
Language:English
Published: United States 20-07-2010
Subjects:
Computer Simulation
Cytokinesis
Kinetics
Monte Carlo Method
Myosins - metabolism
Schizosaccharomyces - cytology
Schizosaccharomyces - metabolism
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Abstract We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that bands of nodes condense into rings when the range of node interactions is larger than the width of the band. Wide bands are unstable to clump formation due to Poisson density fluctuations. We derive expressions for node kinetics and times for ring vs clump formation and test them using numerical simulations. These results suggest clump formation mechanisms in mutant cells.
AbstractList We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that bands of nodes condense into rings when the range of node interactions is larger than the width of the band. Wide bands are unstable to clump formation due to Poisson density fluctuations. We derive expressions for node kinetics and times for ring vs clump formation and test them using numerical simulations. These results suggest clump formation mechanisms in mutant cells.
ArticleNumber 048102
Author Vavylonis, Dimitrios
Ojkic, Nikola
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Snippet We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that...
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SubjectTerms Computer Simulation
Cytokinesis
Kinetics
Monte Carlo Method
Myosins - metabolism
Schizosaccharomyces - cytology
Schizosaccharomyces - metabolism
Title Kinetics of myosin node aggregation into a contractile ring
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